High Tissue TLR5 Expression Predicts Better Outcomes in Colorectal Cancer Patients

<b><i>Background:</i></b> Colorectal cancer (CRC), the third most common globally, caused 881,000 deaths in 2018. Toll-like receptors (TLRs), primary sensors of pathogen-associated molecular patterns and damage-associated patterns, activate innate adaptive immune systems participate development an inflammatory tumor microenvironment. We aimed to explore prognostic value TLR3, TLR5, TLR7, TLR9 tissue expressions CRC patients. <b><i>Methods:</i></b> Using immunohistochemistry, we analyzed microarray samples from 825 patients who underwent surgery between 1982 2002 at Department Surgery, Helsinki University Hospital, Finland. After analyzing a pilot series 205 samples, included only TLR5 TLR7 remainder patient series. evaluated associations expressions, clinicopathologic variables, survival. Kaplan-Meier method, generated survival curves, determining significance using log-rank test. Univariate multivariate analyses relied on Cox proportional hazards model. <b><i>Results:</i></b> The 5-year disease-specific was 55.9% among TLR5-negative (95% confidence interval [CI] 50.6–61.2%) 61.9% CI 56.6–67.2%; <i>p</i> = 0.011, test) TLR5-positive In analysis adjusted for age, sex, stage, location, grade, positive immunoexpression (hazard ratio [HR] 0.74; 95% 0.59–0.92; 0.007) served as independent factor. exhibited no across entire cohort (HR 0.97; 0.78–1.20; 0.754) nor subgroup analyses. <b><i>Conclusions:</i></b> show first time that high expression associates with better prognosis